Kramer was born in Grand Rapids, Michigan on March 26, 1962, and attended the BFA program at the University of Alberta at Edmonton, which led to acting in the theater and some television and movie roles, as well as fight choreography. He moved to Los Angeles at the urging of his friend Gary Sandy. He has 2 daughters named Lenesse and Sedona.
In 1987, Kramer made his first acting debut in The Gunfighters. He also starred in 1990 film Quest for the Mighty Sword. He played Thor in the television movie The Incredible Hulk Returns. Among Kramer's more notable roles have been Little John in Robin Hood: Men in Tights, Bear in American Wedding, and Boris, bodyguard to producer Lee Donowitz, in True Romance. He has also appeared in a number of television series, including Growing Pains, Cheers, Empty Nest, CSI: Crime Scene Investigation, NewsRadio, JAG, Murder, She Wrote, Seinfeld, Phil of the Future, and My Name Is Earl. Kramer also appeared in the Emmy-award winning show Wizards of Waverly Place as Coach Gunderson in the episode "Alex in the Middle". He also made an appearance as a bar patron who bullies John Goodman in an early episode of Roseanne. He was a series regular in the sitcom Bob as Whitey van de Bunt (1993), and appeared in Down Home as the husband of star Judith Ivey.
Kramer continues to work on the stage as a member of the Antaeus Classical Rep Company in Los Angeles, and received an Ovation Award nomination for his role in "The Wood Demon". He co-starred as Bob Duncan on the Disney Channel sitcom Good Luck Charlie from 2010-2014.